The binding site of analgesic receptors has two hydrophobic binding regions in the vicinity of the ionic binding region.

The binding site of analgesic receptors has two hydrophobic binding regions in the vicinity of the ionic binding region. One is responsible for agonist activity and the other is responsible for antagonist activity. Which of the following statements is true?

a) The antagonist hydrophobic binding region is closer to the ionic binding region than the agonist hydrophobic binding region.

b) The agonist hydrophobic binding region is closer to the ionic binding region than the antagonist hydrophobic binding region.

c) The antagonist hydrophobic binding region and agonist hydrophobic bind regions are equidistant from the ionic binding region.

d) The relative positions of the hydrophobic regions vary depending on the type of analgesic receptor concerned.

a- e . Yorta rty an. pgar llstnoutlcns y ‘rlmary entice Deaths (%) Apgar Score (%) 5 6 .3: Primary Service Burn 1,558 Cardiac 3,513 Emergency 2,384

Hello,

I would like assistance with the following 3 problems to verify my answers are correct prior to submission on Friday by midnight. I have not used this service before, so please let me know if you need anything else. Kindest regards, T

Problem #1 (______/20)

At 1 minute after birth and again at 5 minutes, each newborn child is given a numerical rating called an Apgar Score. Possible values of this score are 0, 1, 2, …, 9, 10. A child’s score is determined by five factors: muscle tone, skin color, respiratory effort, strength of heartbeat, and reflex, with a high score  indicating a healthy infant.

The success of this Apgar Score in predicting post-birth problems has led to the use of an Apgar-like score in other medical situations. A recent paper (Anesthesiology, June 2011; see link at the end of this problem) discusses the success the Surgical Apgar Score in many medical subspecialties. In a method similar to the newborn scoring system, the Surgical Apgar Score uses three factors (estimated blood loss (EBL), lowest intraoperative heart rate (HR), and lowest intraoperative mean arterial pressure (MAP)) to assign a score of 0, 1, 2, …, 9, 10, to patients undergoing surgery in the postoperative setting. According to the article, “Strengths of the Surgical Apgar Score include the ability to calculate the score quickly and objectively. The provider could then anticipate the need for further or more aggressive interventions.”

The following table, taken directly from the article, shows the percent of patients receiving one of the Surgical Apgar Scores 0, 1, 2, …, 9, 10 for 21 different primary services. For example, 3.8% (0.038) of all Burn patients received an Apgar score of 3.

For Problem #1, we will focus on the use of the Surgical Apgar Score for Liver transplant. Let the variable  denote the score of a randomly selected Liver transplant patient at a particular hospital. Using Table 4, fill out the probability distribution for the random variable . I put in the first two probabilities for you!

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What is the contour interval of the map (in feet)?

  1. What is the contour interval of the map (in feet)?
  2. Which lettered or named location on the map has the highest elevation and what elevation value is it (Hint: Be sure to use the half rule when applicable)?
  3. Which lettered or named location on the map has the lowest elevation and what elevation value is it (Hint: Be sure to use the half rule when applicable)?
  4. Is it possible to see point D from point F? Explain.
  5. How deep, from the top to its bottom, is the depression on the map (Hint: Be sure to use the half rule when applicable)?

Belts U. Belts was entering a new market in 2002, the selling of conveyor belts to domestic manufacturers. Prior to 2002 U.

U.S. Belts

U. S. Belts was entering a new market in 2002, the selling of conveyor belts to domestic manufacturers. Prior to 2002 U. S. Belts had been one of the top manufacturers of belt webbing from their plant in Springdale, Arkansas. The plant had started production of nylon webbing for the automotive industry (seatbelts) in 1964, and had slowly diversified into other venues. By 1996, the auto industry was only 32% of U. S. Belt’s total sales as measured in volume and 28% in revenue.

U. S. Belts was currently attempting to launch a new product in the industrial conveyor belt market made from aramid fiber webbing. Most conveyor belts are rubber or a neoprene based composite. The rubber or a neoprene based composite belts have a tendency to stretch, overheat or buckle in some applications. These problems will give rubber or neoprene belts a shorter life due to the problems previously discussed and result in quicker belt failure. Rubber or neoprene composite belts are also limited to a fairly straight delivery range. The belts generally have trouble when even a small turn or change in the delivery angle is required.

Aramid fiber is best known a bulletproof or (by the preferred term) bullet resistant material. For example, Kevlar is the DuPont Company’s brand name for aramid fiber. The properties of aramid fiber are legendary. It is flexible, light weight and wear resistant. Aramid fiber is spun in the same way that a spider spins a web, the resulting fiber has tremendous strength, and is heat and cut resistant. The fibers do not rust or corrode, and their strength is unaffected by water. Kevlar’s main weaknesses are that it decomposes under alkaline conditions or when exposed to chorine. While it can have a great tensile strength, sometimes in excess of 4.0 Gpa like all fibers it tends to buckle in compression. (Gpa is a tensile strength scale that is used for comparison. A 4.0Gpa, means that it has 4 times the strength of nylon of comparable thickness)

U. S. Belts has hired you to help develop their new marketing and sales campaign. Most of the company representatives that the sales force from U.S. Belt will be selling to have their background in engineering, and have above average skills in math and technology. Specifically, your job will be to develop the financial aspect of marketing the new belt. In general, this will include appealing to the buyers “cost conscious” nature of switching to the new type of aramid fiber belts. 

A study of the industry and potential U.S. Belt customers revealed some interesting data (Table 1 and Table 2). The cost of the average conveyor belt system for their customers is $300,000. Installation, conversion to new bearings (the new belts require a new type of cool running ball bearing) will cost another $30,000. This expense will be added to the book value of the plants and be eligible for depreciation. A MACRS life class of three years would be employed, even though the aramid fiber belts would last on average 4 years. At the end of the four years the belts would have no economic value and a salvage value of zero. The depreciation on the belts under the current MACRS will be 33%, 45%, 15% and 7% in years 1 through 4 respectively. The average company will have a 11% cost of capital, and an annual tax rate of 28%.

The cost savings with the new belts are lower maintenance costs, far less downtime due to belt slippage, adjustment, and lower bearing replacement costs. The new aramid fiber belts are expected to save the average company $140,000/year. The new aramid fiber belts, however, would not have any useable life after their final year. They would be fully depreciated. The cost of removal would equal the scrap value would give them a net current market value of zero.

In a counter move the rubberized based conveyer belt manufacturers have brought out a newer, longer lasting type of belt that will sell for $210,000. Installation will cost another $20,000. As with the aramid fiber belts, this expense will be added to the book value of the plants and be eligible for depreciation. A MACRS life class of three years would be employed with the same depreciation rates and cost of capital as previously assumed. The newer type of rubberized belt would last 4 years. Also, the new rubberized belt is projected to save the average company $85,000/yr. In most cases the belts being replaced would have some useable life even though they are fully depreciated. The cost of removal minus the scrap value would give them a market values of $35,000. 

Table 1

U.S. Belts New Aramid Fiber Belt

Projected Annual Net Cash Flows

                          Net             Depreciation               Cost Savings              Annual After

Year                 Costs           Tax Savings               (After-Tax)           Tax Cash Flows

0                     $(310,000)                                                                              $(320,000)

1                                               $38,115                     $91,000                     129,115

2                                               $51,975                     $91,000                     142,975

3                                               $17,325                     $91,000                     108,325

4                                                 $8,085                     $91,000                       99,085

Table 2

New Rubberized Conveyor Belts

Projected Annual Net Cash Flows

              Net             Depreciation         Cost Savings    Salvage Value     Annual After

Year     Costs           Tax Savings          (After-Tax)          (After-Tax)  Tax Cash Flows

0         $(208,000)                                                                                         $(218,000)

1                                   $26,565                     $55,250                                 81,815

2                                 $36,225                     $55,250                                  91,475

3                                  $12,075                     $55,250                                  67,325

4                                    $5,635                     $55,250       $22,750              83,635

Your job is to develop a presentable capital budgeting template for U. S. Belt’s sales force. Your model, for the most part, will help non-financial sales representatives sell the new product to both financially experienced and non-financial experienced plant mangers and purchasing agents. Your presentation must be clear, technically correct and easily understandable to both parties. 

Note: Table 1 and table 2 are project assumptions are based off of the figures and calculations provided in the case.

The element lead, Mass = 207.2 g/mol , has a density of 11.35 g/cm3. Find the number of atoms per cubic centimeter.

The element lead, Mass = 207.2 g/mol , has a density of 11.35 g/cm3. Find the number of atoms per cubiccentimeter. If the total gamma ray cross section at 3 MeV is 14 barns,

what are the linearattenuation coefficient and the half-thickness?

I need help on finding the linear attentuation coefficient most of all! And then the half-thickness, I know there are closely related

d growth of Gram-negative organisms on the PEA plate you inoculated, does this negate the usefulness of the PEA as a selective medium? Why or why not?…

If you observed growth of Gram-negative organisms on the PEA plate  you inoculated, does this negate the usefulness of the PEA as a selective medium? Why or why not? Compare the growth on the NA and the PEA plates).

Two air carts of mass = 0.87 and = 0.50 are placed on a frictionless track. Cart 1 is at rest initially, and has a spring bumper with a force…

Two air carts of mass = 0.87 and = 0.50 are placed on a frictionless track. Cart 1 is at rest initially, and has a spring bumper with a force constant of 690 . Cart 2 has a flat metal surface for a bumper, and moves toward the bumper of the stationary cart with an initial speed = 0.69 . Assume that positive -axis is directed toward the direction of motion of cart 2.

I am not sure. Use the alternative energy sources of wind, geothermal and concentrated solar power to replace coal power.

 Need help…I am not sure.

1.   Use the alternative energy sources of wind, geothermal and concentrated solar power to replace coal power. How many wedges can be realistically removed from the projected emissions graph? What is the total number of wedges that have now been removed from the graph?

A spinning disk experiences a constant torque.

A spinning disk experiences a constant torque. Which of the quantities – angular acceleration, tangential acceleration at the disk’s rim, and/or centripetal acceleration at the disk’s rim – is changing as this torque is applied?