Help with explaining and answering questions… so far for question 1 I think E.Coli is the organism.
The patient was an 80-year-old female who 10 days previously had had a cystocele repair performed. At the time of the hospital admission, a urine culture was obtained and revealed >100,000 CFU/ml of an Escherichia coli strain that was susceptible to all antimicrobial agents against which it was tested. Postoperatively, she began a 7-day course of oral cephalexin. She was discharged after an uneventful postoperative course of 3 days. Ten days postoperatively, she presented with a 3-day history of diarrhea. The patient noted multiple watery, loose stools without blood, crampy abdominal pain, and vomiting. She presented with a temperature of 38.2 degrees C, pulse rate of 90/min, respiration rate of 20/min, and blood pressure of 116/53mm Hg. Her white blood cell count was normal, but a large number (53%) of immature polymorphonuclear cells were seen. Physical examination, electrolytes, liver enzymes, and lipase were all within normal limits.
Cultures for Salmonella, Shigella, Yersinia, and Campylobacter spp. were all negative.
- What organism was causing the woman’s diarrhea?
- What in her history was a predisposing factor for her development of this infection? How did it predispose her?
- Why is this organism particularly problematic as a nosocomial pathogen?
- Describe the disease spectrum seen with this organism.
- What virulence factors does this organism produce, and what roles do these factors play in the pathogenesis of disease?
- Discuss three different types of therapeutic strategies that can be used to treat this disease.